[CAS NO. 90332-63-1] 10-Deacetyl-7-xylosyl paclitaxel

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Catalog:	SLK-S0563
Brand:	Selleck
CAS:	90332-63-1

Overview

MDL	-
Molecular Weight	943.98
Molecular Formula	C50H57NO17
SMILES	O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](O[C@]4([C@H](O)[C@@H](O)[C@H](O)CO4)[H])C[C@]1(OC2)[H])C(=O)[C@H](O)C=5C(C)(C)[C@](O)([C@H]3OC(=O)C6=CC=CC=C6)C[C@H](OC([C@@H]([C@@H](NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)O)=O)C5C)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.0593 mL	5.2967 mL	10.5934 mL
5 mM	0.2119 mL	1.0593 mL	2.1187 mL
10 mM	0.1059 mL	0.5297 mL	1.0593 mL
50 mM	0.0212 mL	0.1059 mL	0.2119 mL

Description

10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from , causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic protein, as well as down-regulating expression of anti-apoptotic , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of .

Targets

Bax ^[1]

Bad ^[1]

Bcl-2 ^[1]

Bcl-XL ^[1]

caspase-9 ^[1]

References

[1] Jiang S, et al. Int J Oncol. 2008 Jul;33(1):103-11.

Synonyms

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

10-Deacetyltaxol 7-xyloside

10-Deacetyl-7-xylosyltaxol

7-Xylosyl-10-deacetyltaxol

10-Deacetylpaclitaxel 7-xyloside

7β-Xylosyl-10-deacetyltaxol

10-Deacetyl-7-xylosylpaclitaxel

7-Xylosyl-10-deacetylpaclitaxel

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