Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.8577 mL
19.2886 mL
38.5773 mL
5 mM
0.7715 mL
3.8577 mL
7.7155 mL
10 mM
0.3858 mL
1.9289 mL
3.8577 mL
50 mM
0.0772 mL
0.3858 mL
0.7715 mL
Description
Mizoribine (Bredinin, NSC 289637,HE 69) is an imidazole nucleoside and an immunosuppressant that inhibits with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of and . Mizoribine also inhibits SARS-CoV.
Mizoribine (1-50 mg/mL) is able to inhibit T cell proliferation by 10-100% in a dose-dependent fashion to all stimuli tested. Mizoribine leads to a decrease in intracellular GTP levels, and that repletion of GTP reversed its antiproliferative effects. Mizoribine causes a dose-dependent inhibition of T cell proliferation, which is reversible with the addition of 50 mM guanosine to replete guanine ribonucleotide pools. Mizoribine selectively inhibits guanine ribonucleotide formation in purified T cells, whereas the effect of 6-mercaptopurine (6MP) appears to be more dependent on adenine ribonucleotide depletion. Mizoribine inhibits HCV RNA replication with IC50 of 100 μM.
