[CAS NO. 50924-49-7] Mizoribine

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PRODUCTS SPECIFICATIONS [50924-49-7]

Catelog

SLK-S1384

Brand

Selleck

CAS

50924-49-7

DESCRIPTION [50924-49-7]

Overview

MDL	MFCD00057221
Molecular Weight	259.22
Molecular Formula	C9H13N3O6
SMILES	O[C@H]1[C@@](O[C@H](CO)[C@H]1O)(N2C(O)=C(C(N)=O)N=C2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.8577 mL	19.2886 mL	38.5773 mL
5 mM	0.7715 mL	3.8577 mL	7.7155 mL
10 mM	0.3858 mL	1.9289 mL	3.8577 mL
50 mM	0.0772 mL	0.3858 mL	0.7715 mL

Description

Mizoribine (Bredinin, NSC 289637,HE 69) is an imidazole nucleoside and an immunosuppressant that inhibits with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of and . Mizoribine also inhibits SARS-CoV.

Targets

Monophosphate synthetase ^[2]

In vitro

Mizoribine (1-50 mg/mL) is able to inhibit T cell proliferation by 10-100% in a dose-dependent fashion to all stimuli tested. Mizoribine leads to a decrease in intracellular GTP levels, and that repletion of GTP reversed its antiproliferative effects. Mizoribine causes a dose-dependent inhibition of T cell proliferation, which is reversible with the addition of 50 mM guanosine to replete guanine ribonucleotide pools. Mizoribine selectively inhibits guanine ribonucleotide formation in purified T cells, whereas the effect of 6-mercaptopurine (6MP) appears to be more dependent on adenine ribonucleotide depletion. Mizoribine inhibits HCV RNA replication with IC50 of 100 μM.

References

[1] Turka LA, et al. J Clin Invest, 1991, 87(3), 940-948.
[2] Dayton JS, et al. Mol Pharmacol, 1992, 41(4), 671-676.
[3] Naka K, et al. Biochem Biophys Res Commun, 2005, 330(3), 871-879.
[4] Kikuchi Y, et al. Nephrol Dial Transplant, 2005, 20(8), 1573-1581.

Synonyms

1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-D-ribofuranosyl-

5-Hydroxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide

Bredinin

Mizoribine

β-Bredinin

HE 69

NSC 289637