[CAS NO. 470-17-7] Isoalantolactone

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PRODUCTS SPECIFICATIONS [470-17-7]

Catelog

SLK-S3829

Brand

Selleck

CAS

470-17-7

DESCRIPTION [470-17-7]

Overview

MDL	MFCD08689940
Molecular Weight	232.32
Molecular Formula	C15H20O2
SMILES	C[C@]12[C@@](C[C@]3([C@@](C1)(OC(=O)C3=C)[H])[H])(C(=C)CCC2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.3044 mL	21.5220 mL	43.0441 mL
5 mM	0.8609 mL	4.3044 mL	8.6088 mL
10 mM	0.4304 mL	2.1522 mL	4.3044 mL
50 mM	0.0861 mL	0.4304 mL	0.8609 mL

Description

Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

In vitro

Isoalantolactone inhibits growth and induces apoptosis in pancreatic cancer cells. Isoalantolactone increases the expression of phosphorylated p38 MAPK, Bax, and cleaved caspase-3 and decreases the expression of Bcl-2 in a dose-dependent manner. Isoalantolactone treatment in HeLa cancer cells exhibits cytotoxicity in a dose-dependent manner with a low IC50 value of 8.15 ± 1.16 μM.

In vivo

Isoalantolactone does not induce any acute or chronic toxicity in liver and kidneys of CD1 mice at dose of 100 mg/kg body weight. Isoalantolactone is distributed and eliminated rapidly possibly due to its low-polarity characteristic. A large apparent volume of distribution (138.44 ± 54.14 L) suggests that the lactones may accumulate in certain organs with high concentration after intravenous injection.

References

[1] Muhammad Khan, et al. Int J Biol Sci. 2012, 8(4): 533–547.
[2] L.Venables, et al. South African Journal of Botany. 2016, 103: 216-221.
[3] Renjie Xu, et al. Journal of Chemistry. 2014.

Synonyms

Naphtho[2,3-b]furan-2(3H)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3aR,4aS,8aR,9aR)-

Eudesma-4(14),11(13)-dien-12-oic acid, 8β-hydroxy-, γ-lactone

Isoalantolactone

Naphtho[2,3-b]furan-2(3H)-one, decahydro-8a-methyl-3,5-bis(methylene)-, [3aR-(3aα,4aα,8aβ,9aα)]-

(3aR,4aS,8aR,9aR)-Decahydro-8a-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2(3H)-one

(+)-Isoalantolactone

Isoallantolactone

Isohelenin

5αH-Eudesma-4(15),11(13)-dien-12,8β-olide

NSC 241036