[CAS NO. 23513-14-6] 6-Gingerol

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PRODUCTS SPECIFICATIONS [23513-14-6]

Catelog

SLK-S3836

Brand

Selleck

CAS

23513-14-6

DESCRIPTION [23513-14-6]

Overview

MDL	MFCD00210507
Molecular Weight	294.39
Molecular Formula	C17H26O4
SMILES	C(CC(C[C@H](CCCCC)O)=O)C1=CC(OC)=C(O)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3969 mL	16.9843 mL	33.9685 mL
5 mM	0.6794 mL	3.3969 mL	6.7937 mL
10 mM	0.3397 mL	1.6984 mL	3.3969 mL
50 mM	0.0679 mL	0.3397 mL	0.6794 mL

Description

6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

In vitro

6-gingerol treatment significantly reduces the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner. 6-gingerol induces significant G2/M phase arrest and has slight influence on sub-G1 phase in LoVo cells. Levels of cyclin A, cyclin B1, and CDK1 are diminished; in contrast, levels of the negative cell cycle regulators p27Kip1 and p21Cip1 are increased in response to 6-gingerol treatment. In addition, 6-gingerol treatment elevates intracellular reactive oxygen species (ROS) and phosphorylation level of p53. 6-gingerol is effective in suppressing the transformation, hyperproliferation, and inflammatory processes that initiate and promote carcinogenesis, as well as the later steps of carcinogenesis, namely, angiogenesis and metastasis. 6-gingerol has direct cytotoxic effects on cultures of tumor cells, such as colorectal cancer cells, HL-60 cells and breast cancer cells.

In vivo

6-gingerol inhibits tumor growth in several types of murine tumors, such as B16F1 melanomas, Renca renal cell carcinomas and CT26 colon carcinomas, established by inoculating tumor cells on the flanks of mice, although it does not lead to complete eradication of the tumors. 6-gingerol treatment of tumor-bearing mice causes massive infiltration of CD4 and CD8 T-cells and B220+ B-cells, but reduces the number of CD4+Foxp3+ regulatory T-cells. The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly express IFN-γ, a marker of activation of CTL CD107a cells, and chemokine receptors that are expressed on TH1 cells, such as CXCR3 and CCR5.

References

[1] Ching-Bin Lin, et al. Evidence-Based Complementary and Alternative Medicine. 2012.
[2] Ju SA, et al. Int J Cancer. 2012, 130(11):2618-28.

Synonyms

3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-

3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-

3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-

(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone

(+)-[6]-Gingerol

[6]-Gingerol

(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone

(S)-(+)-[6]Gingerol

(S)-[6]Gingerol

(5S)-[6]-Gingerol

(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

3-Decanone 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-