[CAS NO. 623-05-2] 4-Hydroxybenzyl alcohol

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PRODUCTS SPECIFICATIONS [623-05-2]

Catelog

SLK-S3857

Brand

Selleck

CAS

623-05-2

DESCRIPTION [623-05-2]

Overview

MDL	MFCD00004658
Molecular Weight	124.14
Molecular Formula	C7H8O2
SMILES	C(O)C1=CC=C(O)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.

In vitro

4-hydroxybenzyl alcohol has been shown to suppress inflammation, which is most probably due to its capability of reducing cyclooxygenase activity. HBA acts as a typical pleiotropic agent, which targets multiple mechanisms of angiogenesis, including production of angiogenic growth factors and MMPs, endothelial cell proliferation and migration as well as vascular sprouting and network formation.

In vivo

4-hydroxybenzyl alcohol inhibits the vascularization of newly developing tumors and that this is associated with a reduced growth rate of the malignant tissue. It ameliorates cerebral ischaemic injury due to the inhibition of apoptotic pathways and the up-regulation of protein disulphide isomerase without inducing any toxic effects at doses up to 200 mg/kg. It exerts an anxiolytic-like action via the activation of the 5-hydroxytryptaminergic nervous system.

References

[1] Laschke MW, et al. Life Sci. 2013, 93(1):44-50.

Synonyms

Benzenemethanol, 4-hydroxy-

Benzyl alcohol, p-hydroxy-

4-Hydroxybenzenemethanol

p-Hydroxybenzyl alcohol

4-Methylolphenol

4-Hydroxybenzyl alcohol

p-Methylolphenol

4-(Hydroxymethyl)phenol

α-Hydroxy-p-cresol

p-(Hydroxymethyl)phenol

Gastrodigenin

(4-Hydroxyphenyl)methanol

p-Methoxytoluol

NSC 227926

p-Hydroxybenzenemethanol

p-2-Hydroxybenzyl alcohol