[CAS NO. 10284-63-6] D-Pinitol

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PRODUCTS SPECIFICATIONS [10284-63-6]

Catelog

SLK-S3870

Brand

Selleck

CAS

10284-63-6

DESCRIPTION [10284-63-6]

Overview

MDL	MFCD00216659
Molecular Weight	194.18
Molecular Formula	C7H14O6
SMILES	O(C)[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]1O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.1499 mL	25.7493 mL	51.4986 mL
5 mM	1.0300 mL	5.1499 mL	10.2997 mL
10 mM	0.5150 mL	2.5749 mL	5.1499 mL
50 mM	0.1030 mL	0.5150 mL	1.0300 mL

Description

D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.

In vitro

D-pinitol reduces the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Treatment of prostate cancer cells with D-pinitol reduces mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerts its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-κB activation.

In vivo

D-pinitol exerts an acute and chronically-sustained antihyperglycaemic effect in the murine STZ-induced model of hypoinsulinaemic diabetes. The mechanism of action of D-pinitol does not augment the effect of insulin but might involve an interaction with part of a cellular signalling pathway that links insulin with glucose transport.

References

[1] Lin TH, et al. Int J Mol Sci. 2013, 14(5):9790-802.
[2] Bates SH, et al. Br J Pharmacol. 2000, 130(8):1944-8.

Synonyms

D-chiro-Inositol, 3-O-methyl-

Inositol, 3-O-methyl-, D-chiro-

Pinitol, (+)-

3-O-Methyl-D-chiro-inositol

D-Pinitol

3-O-Methyl-(+)-chiro-inositol

(+)-Pinitol

D-(+)-Pinitol

Pinite (inositol derivative)

Matezit

Sennit

Pinit

Sennitol

d-Pinitol

Pinitol

Inzitol

Pinitol B

D-3-O-Methyl-chiro-inositol

Caro pinitol P

Caro Pinitol P