[CAS NO. 6882-68-4] Sophoridine

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PRODUCTS SPECIFICATIONS [6882-68-4]

Catelog

SLK-S3895

Brand

Selleck

CAS

6882-68-4

DESCRIPTION [6882-68-4]

Overview

MDL	MFCD00238686
Molecular Weight	248.36
Molecular Formula	C15H24N2O
SMILES	O=C1N2[C@@]([C@@]3([C@@]4([C@@](C2)(CCCN4CCC3)[H])[H])[H])(CCC1)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.

In vitro

Sophoridine kills cancer cells but has low cytotoxicity to normal cells. Pancreatic cancer cells are particularly sensitive. Sophoridine inhibits the proliferation of pancreatic cancer cells and induces cell cycle arrest at S phase and mitochondrial-related apoptosis. Moreover, Sophoridine induces a sustained activation of the phosphorylation of ERK and JNK. In addition, Sophoridine provokes the generation of reactive oxygen species (ROS) in pancreatic cancer cells. Sophoridine also triggers significant down-regulated the expression of p27, CDK2, Survivin, Livin, Bcl-2, E2F1 and the transcriptional activity of FoxM1, NF-κb and AP-1, meanwhile, up-regulated the expression of caspase-3/8, p53, Smac, c-JNK and p38-MAPK. Sophoridine significantly inhibits ubiquitin-proteasome in tumor cells.

In vivo

Sophoridine is an effective agent that can inhibit the growth of xenograft pancreatic tumors in vivo with well-tolerated toxicity. Sophoridine attenuates intestinal inflammation in the experimental colitis model, which is associated with the downregulation of ICAM-1 gene expression.

References

[1] Xu Z, et al. J Exp Clin Cancer Res. 2017, 36(1):124.
[2] Wen-Xin Wang, et al. Int J Clin Exp Med. 2015, 8(1): 464–471.
[3] Zhao WC, et al. J Asian Nat Prod Res. 2010, 12(11):925-33.

Synonyms

1H,5H,10H-Dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-

Sophoridine

Matridin-15-one, (5β)-

(7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one

l-Sophoridine

Sophoridin

Dihydro-5-episophocarpine

5-Epidihydrosophocarpine

(-)-Sophoridine

1H,5H,10H-Dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, dodecahydro-, [7aR-(7aα,13aα,13bβ,13cβ)]-