[CAS NO. 541-46-8] Isovaleramide

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PRODUCTS SPECIFICATIONS [541-46-8]

Catalog

SLK-S4116

Brand

Selleck

CAS

541-46-8

DESCRIPTION [541-46-8]

Overview

MDL	-
Molecular Weight	101.15
Molecular Formula	C5H11NO
SMILES	C(C(C)C)C(N)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	9.8863 mL	49.4315 mL	98.8631 mL
5 mM	1.9773 mL	9.8863 mL	19.7726 mL
10 mM	0.9886 mL	4.9432 mL	9.8863 mL
50 mM	0.1977 mL	0.9886 mL	1.9773 mL

Description

Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.

Targets

alcohol dehydrogenase ^[4]

In vitro

Isovaleramide is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3.

References

[1] Giraldo SE, et al. Biomedica, 2010, 30(2), 245-250.
[2] Bialer M, et al. Epilepsy Res, 2004, 61(1-3), 1-48.
[3] Kato Y, et al. Eur J Biochem, 1999, 263(3), 662-670.
[4] Chadha VK, et al. J Med Chem. 1983, 26(6):916-22.

Synonyms

Butanamide, 3-methyl-

Isovaleramide

3-Methylbutanamide

Isovaleric acid amide

3-Methylbutyramide

β-Methylbutyramide

Isopentanamide

NSC 402555

NPS 1776