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Catalog:
SLK-S4246
Brand:
Selleck
CAS:
1986-47-6
Overview
MDL
MFCD00063602
Molecular Weight
169.65
Molecular Formula
C9H12ClN
SMILES
N[C@H]1[C@H](C2=CC=CC=C2)C1.[H]Cl
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
5.8945 mL
29.4724 mL
58.9449 mL
5 mM
1.1789 mL
5.8945 mL
11.7890 mL
10 mM
0.5894 mL
2.9472 mL
5.8945 mL
50 mM
0.1179 mL
0.5894 mL
1.1789 mL
Description
Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a inhibitor, which inhibits CYP2A6 with of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.
R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(−)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes.
In vivo
Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats.
