[CAS NO. 42553-65-1] Crocin

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PRODUCTS SPECIFICATIONS [42553-65-1]

Catelog

SLK-S4758

Brand

Selleck

CAS

42553-65-1

DESCRIPTION [42553-65-1]

Overview

MDL	MFCD11044877
Molecular Weight	976.96
Molecular Formula	C44H64O24
SMILES	C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@@H](OC(/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)\C)\C)/C)/C)=O)[C@H](O)[C@@H](O)[C@@H]2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.0236 mL	5.1179 mL	10.2358 mL
5 mM	0.2047 mL	1.0236 mL	2.0472 mL
10 mM	0.1024 mL	0.5118 mL	1.0236 mL
50 mM	0.0205 mL	0.1024 mL	0.2047 mL

Description

Crocin (Alpha-Crocin, Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L.). It has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer.

In vitro

Crocin can significantly inhibit the proliferation of MCF-7 cells, and induce their apoptosis through mitochondrial signaling pathways including the activation of Caspase-8, upregulation of Bax, the disruption of mitochondrial membrane potential (MMP), and the release of cytochrome c. Crocin decreases cell viability in DLA (Daltons lymphoma) cells, in a concentration- and time-dependent manner.

In vivo

Crocin exhibits a variety of pharmacological effects in mice including inhibition of skin tumor growth, improvement of learning behavior previously impaired by ethanol, anti-hyperlipidemic effects, therapeutic efficacy for colon adenocarcinomas in rats, anti-atherosclerotic effects and anti-oxidant effects in PC-12 cells by increasing GSH synthesis. For Daltons lymphoma models, The lifespan of ascities tumor bearing mice treated with crocin, are found to be significantly increasing and a significant reduction in solid tumour volume is found in crocin treated animals when compared to that of control animals. Crocin also shows significant impact on hematological parameters, like the hemoglobin count and numbers of lymphocytes. It has shown that crocin exhibits beneficial effects on many organs including the nervous system, the most studied, gastrointestinal, cardiovascular, genital, endocrine, immune systems, etc. At pharmacological doses it does not harm liver and other organs' function.

References

[1] Lu P, et al. Int J Clin Exp Med. 2015, 8(11):20316-22.
[2] Bakshi HA, et al. Asian Pac J Cancer Prev. 2009, 10(5):887-90.
[3] Alavizadeh SH, et al. Food Chem Toxicol. 2014, 64:65-80.

Synonyms

β-D-Glucopyranose, 6-O-β-D-glucopyranosyl-, 1,1′-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]

Crocin

8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester

α-Crocin

Crocin 1

all-trans-Crocetin di-β-D-gentiobiosyl ester

Crocetin bis(gentiobiosyl) ester

Crocin 4

Crocetin digentiobioside

Crocin A

trans-Crocetin di(β-D-gentiobiosyl) ester

Crocetin di(β-D-gentiobiosyl) ester

Crocetin di-β-gentiobiosyl ester

Crocin I

trans-Crocin-1

Trans-crocin-1

Kiriyasu Oil Yellow GY