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Catalog:
SLK-S4774
Brand:
Selleck
CAS:
59-00-7
Overview
MDL
MFCD00006754
Molecular Weight
205.17
Molecular Formula
C10H7NO4
SMILES
OC=1C2=C(C(O)=CC(C(O)=O)=N2)C=CC1
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
4.8740 mL
24.3700 mL
48.7401 mL
5 mM
0.9748 mL
4.8740 mL
9.7480 mL
10 mM
0.4874 mL
2.4370 mL
4.8740 mL
50 mM
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Description
Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).
Xanthurenic acid (XA) is considered as a putative neurotransmitter in the CNS, being stored in synaptic vesicles and released by membrane depolarization in a Ca2+-dependent fashion. It is known to inhibit vesicular glutamate transporters (VGLUTs). In heterologous expression systems, Xanthurenic acid could activate both mGlu2 and mGlu3 receptors with high potency, but has no activity on mGlu4 and mGlu7 receptors. Xanthurenic acid induces cell death associated with caspase-3, -8, and -9 activation, nuclear DNA cleavage, and cytochrome C release while not associated with cytoskeleton breakdown -- apoptosis induced by xanthurenic acid does not cause cytoskeleton depolymerization.
In vivo
Systemic administration of Xanthurenic acid in mice produces antipsychotic-like effects in the MK-801-induced model of hyperactivity and peripheral xanthurenic acid can cross the blood-brain barrier, influence the activity of brain regions that are involved in the pathophysiology of schizophrenia.
