[CAS NO. 152121-53-4] PD 169316

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PRODUCTS SPECIFICATIONS [152121-53-4]

Catelog

SLK-S5183

Brand

Selleck

CAS

152121-53-4

DESCRIPTION [152121-53-4]

Overview

MDL	MFCD12405019
Molecular Weight	360.34
Molecular Formula	C20H13FN4O2
SMILES	O=[N+](C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)[O-]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7752 mL	13.8758 mL	27.7516 mL
5 mM	0.5550 mL	2.7752 mL	5.5503 mL
10 mM	0.2775 mL	1.3876 mL	2.7752 mL
50 mM	-	-	-

Description

PD 169316 is a potent, selective and cell-permeable inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both and . PD169316 shows antiviral activity against .

Targets

TGF-β ^[1]	Activin A ^[1]	Enterovirus71 ^[2]	p38 MAPK ^[1] (Cell-free assay)
			89 nM

In vitro

Inhibition of the P38 kinase activity using 0.5 μM PD169316 significantly changes the proliferation rate and extent of apoptosis; the effects of 0.2 μM PD169316 are not significant. The level of P-STAT1 (Tyr701) decreases with 0.5 μM PD169316, which is probably due to P38 inhibition.

References

[1] Dulay RM, et al. PLoS One. 2021 May 28;16(5):e0252541.
[2] Zhang Z, et al. Virology. 2017 Aug;508:150-158.
[1] Fu Y, et al. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7.