[CAS NO. 152121-53-4] PD 169316
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PRODUCTS SPECIFICATIONS [152121-53-4]
Catalog
SLK-S5183
Brand
Selleck
CAS
152121-53-4
DESCRIPTION [152121-53-4]
Overview
| MDL | MFCD12405019 |
|---|---|
| Molecular Weight | 360.34 |
| Molecular Formula | C20H13FN4O2 |
| SMILES | O=[N+](C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)[O-] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7752 mL | 13.8758 mL | 27.7516 mL |
| 5 mM | 0.5550 mL | 2.7752 mL | 5.5503 mL |
| 10 mM | 0.2775 mL | 1.3876 mL | 2.7752 mL |
| 50 mM | - | - | - |
Description
PD 169316 is a potent, selective and cell-permeable inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both and . PD169316 shows antiviral activity against .
In vitro
Inhibition of the P38 kinase activity using 0.5 μM PD169316 significantly changes the proliferation rate and extent of apoptosis; the effects of 0.2 μM PD169316 are not significant. The level of P-STAT1 (Tyr701) decreases with 0.5 μM PD169316, which is probably due to P38 inhibition.
References
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