[CAS NO. 1956370-21-0] RIPA-56

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PRODUCTS SPECIFICATIONS [1956370-21-0]

Catelog

SLK-S6511

Brand

Selleck

CAS

1956370-21-0

DESCRIPTION [1956370-21-0]

Overview

MDL	MFCD30738006
Molecular Weight	221.30
Molecular Formula	C13H19NO2
SMILES	CCC(C)(C)C(N(CC1=CC=CC=C1)O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.5188 mL	22.5938 mL	45.1875 mL
5 mM	0.9038 mL	4.5188 mL	9.0375 mL
10 mM	0.4519 mL	2.2594 mL	4.5188 mL
50 mM	0.0904 mL	0.4519 mL	0.9038 mL

Description

RIPA-56 is a highly-potent, selective, and metabolically stable inhibitor.

Targets

RIP1 ^[1]
(Cell-free)

13 nM

In vitro

RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM. It showed no inhibition of RIP3 kinase activity at a 10 µM concentration. RIPA-56 does not inhibit IDO activity at a concentration of 200 µM, which represents an estimated 10,000-fold selectivity window based on the RIP1 ADP-Glo activity of 13 nM.

References

[1] Ren Y, et al. J Med Chem. 2017, 60(3):972-986.