[CAS NO. 151358-47-3] DIM-C-pPhOH

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PRODUCTS SPECIFICATIONS [151358-47-3]

Catalog

SLK-S6799

Brand

Selleck

CAS

151358-47-3

DESCRIPTION [151358-47-3]

Overview

MDL	MFCD03723253
Molecular Weight	338.40
Molecular Formula	C23H18N2O
SMILES	OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL

Description

DIM-C-pPhOH (C-DIM8, CDIM8) is a antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.

Targets

Nur77 ^[1] (786-O cells based assay)	Nur77 ^[1] (ACHN cells based assay)
13.0 μM	13.6 μM

References

[1] Hedrick E, et al. PLoS One. 2015 Jun 2;10(6):e0128308.