[CAS NO. 957135-43-2] SM-164

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PRODUCTS SPECIFICATIONS [957135-43-2]

Catalog

SLK-S7089

Brand

Selleck

CAS

957135-43-2

DESCRIPTION [957135-43-2]

Overview

MDL	MFCD28167763
Molecular Weight	1121.42
Molecular Formula	C62H84N14O6
SMILES	C[C@H](NC)C(N[C@H]1CCCC[C@](CC[C@H]2C(N[C@@H](C3=CC=CC=C3)C4=CN(CCCCC5=CC=C(CCCCN6N=NC([C@@H](NC([C@@H]7CC[C@@](CCCC[C@@H]8NC([C@@H](NC)C)=O)([H])N7C8=O)=O)C9=CC=CC=C9)=C6)C=C5)N=N4)=O)([H])N2C1=O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	0.8917 mL	4.4586 mL	8.9173 mL
5 mM	-	-	-
10 mM	-	-	-
50 mM	-	-	-

Description

SM-164 is a potent, non-peptide, cell-permeable antagonist of that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces and tumor regression.

Features

The potency of bivalent SM-164 in binding, functional, and cellular assays is 2−3 orders of magnitude higher than its corresponding monovalent Smac mimetics.

Targets

XIAP ^[1]
(Cell-free assay)

1.39 nM