[CAS NO. 521937-07-5] CID755673
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PRODUCTS SPECIFICATIONS [521937-07-5]
Catalog
SLK-S7188
Brand
Selleck
CAS
521937-07-5
DESCRIPTION [521937-07-5]
Overview
| MDL | MFCD03828155 |
|---|---|
| Molecular Weight | 217.22 |
| Molecular Formula | C12H11NO3 |
| SMILES | O=C1NCCCC2=C1OC3=CC=C(O)C=C32 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6036 mL | 23.0181 mL | 46.0363 mL |
| 5 mM | 0.9207 mL | 4.6036 mL | 9.2073 mL |
| 10 mM | 0.4604 mL | 2.3018 mL | 4.6036 mL |
| 50 mM | 0.0921 mL | 0.4604 mL | 0.9207 mL |
Description
CID755673 is a cell-active pan- inhibitor with of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.
In vitro
In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocks PMA-induced nuclear export of HDAC5, and blocks PKD-mediated protein transport. In prostate cancer cells, CID755673 potently blocks cell migration and invasion, and also shows inhibition activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alter primary human NK cell effector functions.
In vivo
CID755673, via PKD/PKD1 inhibition, significantly ameliorates necrosis and severity of pancreatitis in a rat acute pancreatitis model.
References
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