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Catalog:
SLK-S7217
Brand:
Selleck
CAS:
300586-90-7
Overview
MDL
MFCD00572806
Molecular Weight
237.26
Molecular Formula
C14H11N3O
SMILES
O=C(NC1=CC2=C(NC=C2)C=N1)C3=CC=CC=C3
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
4.2148 mL
21.0739 mL
42.1479 mL
5 mM
0.8430 mL
4.2148 mL
8.4296 mL
10 mM
0.4215 mL
2.1074 mL
4.2148 mL
50 mM
0.0843 mL
0.4215 mL
0.8430 mL
Description
OAC1 (Oct4-activating compound 1, BAS 00287861) can enhance the efficiency of reprogramming. OAC1 can activate both Oct4 and Nanog promoter-driven luciferase reporter genes.
OAC1 at 1 μM enhances reprogramming efficiency by activating both Oct4 and Nanog promoter-driven luciferase reporter genes. Furthermore, OAC1 enhances the pluripotent stem cells (iPSC) reprogramming efficiency and accelerates the reprogramming process in the quartet reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) treated mouse embryonic fibroblasts (MEFs). The iPSC colonies derived using OAC1 along with the quartet factors exhibits typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency via increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. While it doesn’t inhibit the p53-p21 pathway or activate the Wnt-β-catenin signaling. OAC1 may be used to enhance the reprogramming of somatic cells to a pluripotent state.
