[CAS NO. 571203-78-6] Erastin
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PRODUCTS SPECIFICATIONS [571203-78-6]
Catelog
SLK-S7242
Brand
Selleck
CAS
571203-78-6
DESCRIPTION [571203-78-6]
Overview
| MDL | MFCD09837984 |
|---|---|
| Molecular Weight | 547.04 |
| Molecular Formula | C30H31ClN4O4 |
| SMILES | O=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5 |
For research use only.
Storage
3 years -20°C powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8280 mL | 9.1401 mL | 18.2802 mL |
| 5 mM | 0.3656 mL | 1.8280 mL | 3.6560 mL |
| 10 mM | 0.1828 mL | 0.9140 mL | 1.8280 mL |
| 50 mM | - | - | - |
Description
Erastin is a activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS.
Targets
| Ferroptosis [1] |
In vitro
Erastin is selectively lethal to oncogenic RAS-mutant cell lines, and triggers a unique iron-dependent form of non-apoptotic cell death called ferroptosis. Erastin binds directly to VDAC2 and causes mitochondrial damage via ROS production in an NADH-dependent manner, which induces cell death in some tumor cells harbouring activating mutations in the RAS-RAF-MEK pathway. In addition, erastin, via inducing ROS-mediated CID (Caspase-independent cell death), strongly enhances the effect of cisplatin in WT EGFR cells.
References
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