[CAS NO. 571203-78-6]  Erastin

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PRODUCTS SPECIFICATIONS [571203-78-6]

Catelog
SLK-S7242
Brand
Selleck
CAS
571203-78-6

DESCRIPTION [571203-78-6]

Overview

MDLMFCD09837984
Molecular Weight547.04
Molecular FormulaC30H31ClN4O4
SMILESO=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5

For research use only.

Storage

3 years -20°C powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.8280 mL9.1401 mL18.2802 mL
5 mM0.3656 mL1.8280 mL3.6560 mL
10 mM0.1828 mL0.9140 mL1.8280 mL
50 mM---

Description

Erastin is a activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS.

Targets

Ferroptosis [1]

In vitro

Erastin is selectively lethal to oncogenic RAS-mutant cell lines, and triggers a unique iron-dependent form of non-apoptotic cell death called ferroptosis. Erastin binds directly to VDAC2 and causes mitochondrial damage via ROS production in an NADH-dependent manner, which induces cell death in some tumor cells harbouring activating mutations in the RAS-RAF-MEK pathway. In addition, erastin, via inducing ROS-mediated CID (Caspase-independent cell death), strongly enhances the effect of cisplatin in WT EGFR cells.