[CAS NO. 717824-30-1] Vidofludimus

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PRODUCTS SPECIFICATIONS [717824-30-1]

Catelog

SLK-S7262

Brand

Selleck

CAS

717824-30-1

DESCRIPTION [717824-30-1]

Overview

MDL	MFCD18633262
Molecular Weight	355.36
Molecular Formula	C20H18FNO4
SMILES	C(NC1=C(F)C=C(C=C1)C2=CC(OC)=CC=C2)(=O)C3=C(C(O)=O)CCC3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8140 mL	14.0702 mL	28.1405 mL
5 mM	0.5628 mL	2.8140 mL	5.6281 mL
10 mM	0.2814 mL	1.4070 mL	2.8140 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL

Description

Vidofludimus (SC12267, 4SC-101) is an orally active and potent inhibitor with of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.

Targets

Human DHODH ^[1]

134 nM

In vitro

Vidofludimus causes a concentration dependent inhibition of phytohemagglutinin-stimulated PBMC proliferation via the inhibition of pyrimidine de novo synthesis. Vidofludimus attenuates IL-17 secretion from colonic strips by inhibition of STAT3 and NF-κB activation.

In vivo

In MRL mice, Vidofludimus (300 mg/kg, p.o.) reduces systemic autoimmunity and improves Lupus Nephritis. In Rats, Vidofludimus (60 mg/kg, p.o.) effectively reduces macroscopic and histological pathology and the numbers of CD3+ T cells. In a rat model of renal transplantation, Vidofludimus (20 mg/kg, p.o.) prolongs survival, paralleled by amelioration of histologic signs of acute rejection.

References

[1] Kulkarni OP, et al. Am J Pathol. 2010, 176(6), 2840-2847.
[2] Fitzpatrick LR, et al. J Pharmacol Exp Ther. 2012, 342(3), 850-860.
[3] Rusai K, et al. Transplantation. 2012, 93(11), 1101-1107.

Synonyms

1-Cyclopentene-1-carboxylic acid, 2-[[(3-fluoro-3′-methoxy[1,1′-biphenyl]-4-yl)amino]carbonyl]-

2-[[(3-Fluoro-3′-methoxy[1,1′-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid

Vidofludimus

2-((3-Fluoro-3′-methoxy-[1,1′-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid

SC12267