[CAS NO. 717824-30-1]  Vidofludimus

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PRODUCTS SPECIFICATIONS [717824-30-1]

Catelog
SLK-S7262
Brand
Selleck
CAS
717824-30-1

DESCRIPTION [717824-30-1]

Overview

MDLMFCD18633262
Molecular Weight355.36
Molecular FormulaC20H18FNO4
SMILESC(NC1=C(F)C=C(C=C1)C2=CC(OC)=CC=C2)(=O)C3=C(C(O)=O)CCC3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.8140 mL14.0702 mL28.1405 mL
5 mM0.5628 mL2.8140 mL5.6281 mL
10 mM0.2814 mL1.4070 mL2.8140 mL
50 mM0.0563 mL0.2814 mL0.5628 mL

Description

Vidofludimus (SC12267, 4SC-101) is an orally active and potent inhibitor with of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.

Targets

Human DHODH [1]
134 nM

In vitro

Vidofludimus causes a concentration dependent inhibition of phytohemagglutinin-stimulated PBMC proliferation via the inhibition of pyrimidine de novo synthesis. Vidofludimus attenuates IL-17 secretion from colonic strips by inhibition of STAT3 and NF-κB activation.

In vivo

In MRL mice, Vidofludimus (300 mg/kg, p.o.) reduces systemic autoimmunity and improves Lupus Nephritis. In Rats, Vidofludimus (60 mg/kg, p.o.) effectively reduces macroscopic and histological pathology and the numbers of CD3+ T cells. In a rat model of renal transplantation, Vidofludimus (20 mg/kg, p.o.) prolongs survival, paralleled by amelioration of histologic signs of acute rejection.


Synonyms

1-Cyclopentene-1-carboxylic acid, 2-[[(3-fluoro-3′-methoxy[1,1′-biphenyl]-4-yl)amino]carbonyl]-
2-[[(3-Fluoro-3′-methoxy[1,1′-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid
Vidofludimus
2-((3-Fluoro-3′-methoxy-[1,1′-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
SC12267