[CAS NO. 913822-46-5] SC75741
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PRODUCTS SPECIFICATIONS [913822-46-5]
Catelog
SLK-S7273
Brand
Selleck
CAS
913822-46-5
DESCRIPTION [913822-46-5]
Overview
| MDL | MFCD18206785 |
|---|---|
| Molecular Weight | 565.67 |
| Molecular Formula | C29H23N7O2S2 |
| SMILES | O=C(C1=CSC(C2CCN(C3=C4C(C=CS4)=NC=N3)CC2)=N1)NC5=NC6=CC=C(C(C7=CC=CC=C7)=O)C=C6N5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7678 mL | 8.8391 mL | 17.6782 mL |
| 5 mM | 0.3536 mL | 1.7678 mL | 3.5356 mL |
| 10 mM | 0.1768 mL | 0.8839 mL | 1.7678 mL |
| 50 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL |
Description
SC75741 is a potent inhibitor with of 200 nM. SC75741 efficiently blocks influenza virus propagation.
Features
NF-κB-selective inhibitor.
Targets
| NF-κB [1] (Cell-based NF-κB reporter gene assay) |
| 200 nM(EC50) |
In vitro
SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants.
In vivo
SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.
References
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