[CAS NO. 854847-61-3] HLY78
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PRODUCTS SPECIFICATIONS [854847-61-3]
Catelog
SLK-S7274
Brand
Selleck
CAS
854847-61-3
DESCRIPTION [854847-61-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 267.32 |
| Molecular Formula | C17H17NO2 |
| SMILES | - |
For research use only.
Storage
2 years -80 in solvent
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7408 mL | 18.7042 mL | 37.4083 mL |
| 5 mM | 0.7482 mL | 3.7408 mL | 7.4817 mL |
| 10 mM | 0.3741 mL | 1.8704 mL | 3.7408 mL |
| 50 mM | 0.0748 mL | 0.3741 mL | 0.7482 mL |
Description
HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway.
In vitro
HLY78 is an activator for the Wnt/β-catenin signaling pathway, which acts upstream of β-catenin and functions only in the presence of the Wnt3a ligand, and targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
References
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