[CAS NO. 1222800-79-4] ML324
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PRODUCTS SPECIFICATIONS [1222800-79-4]
Catelog
SLK-S7296
Brand
Selleck
CAS
1222800-79-4
DESCRIPTION [1222800-79-4]
Overview
| MDL | MFCD28053518 |
|---|---|
| Molecular Weight | 349.43 |
| Molecular Formula | C21H23N3O2 |
| SMILES | O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8618 mL | 14.3090 mL | 28.6180 mL |
| 5 mM | 0.5724 mL | 2.8618 mL | 5.7236 mL |
| 10 mM | 0.2862 mL | 1.4309 mL | 2.8618 mL |
| 50 mM | 0.0572 mL | 0.2862 mL | 0.5724 mL |
Description
ML324 is a selective inhibitor of with of 920 nM.
Targets
| JMJD2 [1] (Cell-free assay) |
| 920 nM |
In vitro
ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.
In vivo
In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation.
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