[CAS NO. 1222800-79-4]  ML324

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PRODUCTS SPECIFICATIONS [1222800-79-4]

Catelog
SLK-S7296
Brand
Selleck
CAS
1222800-79-4

DESCRIPTION [1222800-79-4]

Overview

MDLMFCD28053518
Molecular Weight349.43
Molecular FormulaC21H23N3O2
SMILESO=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.8618 mL14.3090 mL28.6180 mL
5 mM0.5724 mL2.8618 mL5.7236 mL
10 mM0.2862 mL1.4309 mL2.8618 mL
50 mM0.0572 mL0.2862 mL0.5724 mL

Description

ML324 is a selective inhibitor of with of 920 nM.

Targets

JMJD2 [1]
(Cell-free assay)
920 nM

In vitro

ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.

In vivo

In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation.