[CAS NO. 500287-72-9]  Rilpivirine

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [500287-72-9]

Catelog
SLK-S7303
Brand
Selleck
CAS
500287-72-9

DESCRIPTION [500287-72-9]

Overview

MDLMFCD11046372
Molecular Weight366.42
Molecular FormulaC22H18N6
SMILESN(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.7291 mL13.6455 mL27.2911 mL
5 mM0.5458 mL2.7291 mL5.4582 mL
10 mM0.2729 mL1.3646 mL2.7291 mL
50 mM0.0546 mL0.2729 mL0.5458 mL

Description

Rilpivirine (R278474, TMC27, DB08864) is a , and used to treat HIV-1 infection.

Features

Approved anti-HIV drug with longer half-life and reduced side-effect profile than older NNRTIs.

Targets

Reverse transcriptase [1]

In vitro

Rilpivirine shows antiviral activity with EC50 ranging from 0.1 nM to 2 nM against wild-type and selected site-directed single and double mutants of HIV-1. Rilpivirine inhibits viral replication at concentrations at which first-generation NNRTIs could not suppress replication, and produces a high genetic barrier to resistance development.

In vivo

After iv administration of Rilpivirine, Elimination half-life ranges from 4.4 h in rat to 31 h in dog. After oral administration of Rilpivirine in PEG 400, half-life ranges between 2.8 h in rat and 39 h in dog.


Synonyms

Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
Rilpivirine
R 278474
TMC 278
Rekambys