Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.9028 mL
9.5142 mL
19.0284 mL
5 mM
0.3806 mL
1.9028 mL
3.8057 mL
10 mM
0.1903 mL
0.9514 mL
1.9028 mL
50 mM
0.0381 mL
0.1903 mL
0.3806 mL
Description
BAY 87-2243 is a potent and selective inhibitor. BAY 87-2243 inhibits activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and . BAY 87-2243 exerts antitumor activity. Phase 1.
BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively. In hypoxic lung cancer H460 cells, BAY 87-2243 suppresses HIF target gene expression, and inhibits HIF-1α protein accumulation. Under glucose depletion, BAY 87-2243 inhibits cell proliferation via interference with mitochondrial function.
In vivo
In H460 xenograft mouse model, BAY 87-2243 (4 mg/kg p.o.) reduces tumor weight, HIF-1α protein, and HIF-1 target gene expression levels.
