[CAS NO. 345630-40-2] SF1670
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PRODUCTS SPECIFICATIONS [345630-40-2]
Catalog
SLK-S7310
Brand
Selleck
CAS
345630-40-2
DESCRIPTION [345630-40-2]
Overview
| MDL | MFCD06411448 |
|---|---|
| Molecular Weight | 307.34 |
| Molecular Formula | C19H17NO3 |
| SMILES | CC(C)(C)C(NC(C=C1C2=O)=CC=C1C3=C(C2=O)C=CC=C3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2537 mL | 16.2686 mL | 32.5373 mL |
| 5 mM | 0.6507 mL | 3.2537 mL | 6.5075 mL |
| 10 mM | 0.3254 mL | 1.6269 mL | 3.2537 mL |
| 50 mM | 0.0651 mL | 0.3254 mL | 0.6507 mL |
Description
SF1670 is a highly potent and specific inhibitor with IC50 of 2 μM.
Targets
| PTEN [1] |
| 2 μM |
In vitro
SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions.
In vivo
Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia.
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