[CAS NO. 1135695-98-5] Q-VD-Oph
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PRODUCTS SPECIFICATIONS [1135695-98-5]
Catalog
SLK-S7311
Brand
Selleck
CAS
1135695-98-5
DESCRIPTION [1135695-98-5]
Overview
| MDL | MFCD08669741 |
|---|---|
| Molecular Weight | 513.49 |
| Molecular Formula | C26H25F2N3O6 |
| SMILES | O=C(O)C[C@H](NC([C@@H](NC(C1=NC2=CC=CC=C2C=C1)=O)C(C)C)=O)C(COC3=C(F)C=CC=C3F)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9475 mL | 9.7373 mL | 19.4746 mL |
| 5 mM | 0.3895 mL | 1.9475 mL | 3.8949 mL |
| 10 mM | 0.1947 mL | 0.9737 mL | 1.9475 mL |
| 50 mM | 0.0389 mL | 0.1947 mL | 0.3895 mL |
Description
Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan- inhibitor with ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.
Targets
In vitro
Q-VD-OPh （5-100 μM） potently inhibits Actinomycin D-induced DNA laddering and subsequent apoptosis with minimal toxicity in WEHI 231 cells. Q-VD-OPh prevents caspase mediated cleavage of PARP and activation of the major initiator and effector caspases. Q-VD-OPh protects cardiac myocytes from virus-induced apoptosis in vitro.
In vivo
Q-VD-OPh inhibits caspase-1 activity, IL-18 protein expression, and neutrophil infiltration during ischemic ARF in mice. In vivo, caspase inhibition by Q-VD-OPh provides protection from virus-induced myocardial injury, with a significant reduction in caspase-3 activity. In TgCRND8 mice, Q-VD-OPh inhibits caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage.
References
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