[CAS NO. 210344-98-2] Z-IETD-FMK
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PRODUCTS SPECIFICATIONS [210344-98-2]
Catelog
SLK-S7314
Brand
Selleck
CAS
210344-98-2
DESCRIPTION [210344-98-2]
Overview
| MDL | MFCD03490491 |
|---|---|
| Molecular Weight | 654.68 |
| Molecular Formula | C30H43FN4O11 |
| SMILES | COC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)[C@H](CC)C)=O)CCC(OC)=O)=O)[C@@H](C)O)=O)C(CF)=O)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5275 mL | 7.6373 mL | 15.2746 mL |
| 5 mM | 0.3055 mL | 1.5275 mL | 3.0549 mL |
| 10 mM | 0.1527 mL | 0.7637 mL | 1.5275 mL |
| 50 mM | 0.0305 mL | 0.1527 mL | 0.3055 mL |
Description
Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK) is a specific inhibitor. Z-IETD-FMK is also an inhibitor of granzyme B.
Targets
| Caspase-8 [1] |
In vitro
Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.
References
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