[CAS NO. 26305-03-3]  Pepstatin A

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PRODUCTS SPECIFICATIONS [26305-03-3]

Catelog
SLK-S7381
Brand
Selleck
CAS
26305-03-3

DESCRIPTION [26305-03-3]

Overview

MDLMFCD00060740
Molecular Weight685.89
Molecular FormulaC34H63N5O9
SMILESCC(C)CC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)=O)=O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.4580 mL7.2898 mL14.5796 mL
5 mM0.2916 mL1.4580 mL2.9159 mL
10 mM0.1458 mL0.7290 mL1.4580 mL
50 mM0.0292 mL0.1458 mL0.2916 mL

Description

Pepstatin A (Pepstatin) is a potent inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of and . Pepstatin A inhibits by suppressing lysosomal proteases.

Targets

aspartic protease [1]cathepsins D [2]cathepsins E [2]

In vitro

Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, pepstatin A inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. Pepstatin A laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression.