[CAS NO. 26305-03-3] Pepstatin A
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PRODUCTS SPECIFICATIONS [26305-03-3]
Catalog
SLK-S7381
Brand
Selleck
CAS
26305-03-3
DESCRIPTION [26305-03-3]
Overview
| MDL | MFCD00060740 |
|---|---|
| Molecular Weight | 685.89 |
| Molecular Formula | C34H63N5O9 |
| SMILES | CC(C)CC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)=O)=O)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4580 mL | 7.2898 mL | 14.5796 mL |
| 5 mM | 0.2916 mL | 1.4580 mL | 2.9159 mL |
| 10 mM | 0.1458 mL | 0.7290 mL | 1.4580 mL |
| 50 mM | 0.0292 mL | 0.1458 mL | 0.2916 mL |
Description
Pepstatin A (Pepstatin) is a potent inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of and . Pepstatin A inhibits by suppressing lysosomal proteases.
In vitro
Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, pepstatin A inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. Pepstatin A laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression.
References
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