[CAS NO. 950455-15-9] Liproxstatin-1

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PRODUCTS SPECIFICATIONS [950455-15-9]

Catelog

SLK-S7699

Brand

Selleck

CAS

950455-15-9

DESCRIPTION [950455-15-9]

Overview

MDL	MFCD14948691
Molecular Weight	340.85
Molecular Formula	C19H21ClN4
SMILES	ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.9338 mL	14.6692 mL	29.3384 mL
5 mM	0.5868 mL	2.9338 mL	5.8677 mL
10 mM	0.2934 mL	1.4669 mL	2.9338 mL
50 mM	0.0587 mL	0.2934 mL	0.5868 mL

Description

Liproxstatin-1 is a potent inhibitor with an IC50 of 22 nM.

Targets

ferroptosis ^[1]
(Cell-free assay)

22 nM

In vitro

Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and HO (200 µM).

In vivo

Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.

References

[1] Friedmann Angeli JP, et al. Nat Cell Biol. 2014, 16(12):1180-1191.