[CAS NO. 1430844-80-6]  A-1331852

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PRODUCTS SPECIFICATIONS [1430844-80-6]

Catelog
SLK-S7801
Brand
Selleck
CAS
1430844-80-6

DESCRIPTION [1430844-80-6]

Overview

MDL-
Molecular Weight658.81
Molecular FormulaC38H38N6O3S
SMILESO=C(O)C1=NC(N2CC3=C(C=CC=C3C(NC4=NC5=CC=CC=C5S4)=O)CC2)=CC=C1C6=C(C)N(CC78CC9CC(C8)CC(C9)C7)N=C6

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.5179 mL7.5894 mL15.1789 mL
5 mM0.3036 mL1.5179 mL3.0358 mL
10 mM0.1518 mL0.7589 mL1.5179 mL
50 mM0.0304 mL0.1518 mL0.3036 mL

Description

A-1331852 is a potent and selective inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.

Targets

Bcl-xL [1]
(Cell-free assay)
<0.01 nM(Ki)

In vitro

A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at low nanomolar concentrations as early as 1 h post-treatment.

In vivo

A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent.