[CAS NO. 1430844-80-6] A-1331852
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PRODUCTS SPECIFICATIONS [1430844-80-6]
Catalog
SLK-S7801
Brand
Selleck
CAS
1430844-80-6
DESCRIPTION [1430844-80-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 658.81 |
| Molecular Formula | C38H38N6O3S |
| SMILES | O=C(O)C1=NC(N2CC3=C(C=CC=C3C(NC4=NC5=CC=CC=C5S4)=O)CC2)=CC=C1C6=C(C)N(CC78CC9CC(C8)CC(C9)C7)N=C6 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5179 mL | 7.5894 mL | 15.1789 mL |
| 5 mM | 0.3036 mL | 1.5179 mL | 3.0358 mL |
| 10 mM | 0.1518 mL | 0.7589 mL | 1.5179 mL |
| 50 mM | 0.0304 mL | 0.1518 mL | 0.3036 mL |
Description
A-1331852 is a potent and selective inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.
Targets
| Bcl-xL [1] (Cell-free assay) |
| <0.01 nM(Ki) |
In vitro
A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at low
nanomolar concentrations as early as 1 h post-treatment.
In vivo
A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent.
References
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