Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.5179 mL
7.5894 mL
15.1789 mL
5 mM
0.3036 mL
1.5179 mL
3.0358 mL
10 mM
0.1518 mL
0.7589 mL
1.5179 mL
50 mM
0.0304 mL
0.1518 mL
0.3036 mL
Description
A-1331852 is a potent and selective inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.
A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at low
nanomolar concentrations as early as 1 h post-treatment.
In vivo
A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent.
