[CAS NO. 379270-37-8] Tenofovir Alafenamide (GS-7340)

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PRODUCTS SPECIFICATIONS [379270-37-8]

Catelog

SLK-S7856

Brand

Selleck

CAS

379270-37-8

DESCRIPTION [379270-37-8]

Overview

MDL	MFCD23843796
Molecular Weight	476.47
Molecular Formula	C21H29N6O5P
SMILES	C([C@H](OCP(OC1=CC=CC=C1)(N[C@H](C(OC(C)C)=O)C)=O)C)N2C=3C(N=C2)=C(N)N=CN3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0988 mL	10.4938 mL	20.9877 mL
5 mM	0.4198 mL	2.0988 mL	4.1975 mL
10 mM	0.2099 mL	1.0494 mL	2.0988 mL
50 mM	0.0420 mL	0.2099 mL	0.4198 mL

Description

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a inhibitor, used to treat HIV and Hepatitis B.

Targets

Reverse transcriptase ^[1]

In vitro

GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP.

In vivo

In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue.

References

[1] Chapman H, et al. Nucleosides Nucleotides Nucleic Acids. 2001, 20(4-7), 1085-10[90.
[2] Lee WA, et al. Antimicrob Agents Chemother. 2005, 49(5), 1898-1906.
[3] Murakami E, et al. Antimicrob Agents Chemother. 2015, 59(6), 3563-3569.

Synonyms

L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester

GS 7340

Tenofovir alafenamide

4: PN: WO2016077321 SEQID: 4 claimed sequence

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