[CAS NO. 141400-58-0] PX-12
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PRODUCTS SPECIFICATIONS [141400-58-0]
Catalog
SLK-S7947
Brand
Selleck
CAS
141400-58-0
DESCRIPTION [141400-58-0]
Overview
| MDL | MFCD18086851 |
|---|---|
| Molecular Weight | 188.31 |
| Molecular Formula | C7H12N2S2 |
| SMILES | CCC(SSC1=NC=CN1)C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.3104 mL | 26.5520 mL | 53.1039 mL |
| 5 mM | 1.0621 mL | 5.3104 mL | 10.6208 mL |
| 10 mM | 0.5310 mL | 2.6552 mL | 5.3104 mL |
| 50 mM | 0.1062 mL | 0.5310 mL | 1.0621 mL |
Description
PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.
Targets
| Trx-1 [1] |
In vitro
In MCF-7 and HT-29 cells, PX-12 prevents the hypoxia (1% oxygen)-induced increase in HIF-1alpha protein, and decreases HIF-1-trans-activating activity, VEGF formation, and inducible nitric oxide synthase. PX-12 also inhibits the growth of MCF-7 and HT-29 cells with IC50s of 1.9 μM and 2.9μM, respectively. PX-12 also inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase. In A549 cells, PX-12 inhibits cell growth via G2/M phase arrest, and Bax-mediated and ROS-dependent apoptosis. In hepatocelluar carcinoma cells, PX-12 exerts a synergistic effect with 5-FU to significantly suppress tumorigenicity.
In vivo
In mice bearing MCF-7 tumor xenografts, PX-12 (12 mg/kg, i.p.) decreases HIF-1α and VEGF protein levels and microvessel density.
References
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