[CAS NO. 380315-80-0]  Tenovin-1

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PRODUCTS SPECIFICATIONS [380315-80-0]

Catelog
SLK-S8000
Brand
Selleck
CAS
380315-80-0

DESCRIPTION [380315-80-0]

Overview

MDLMFCD02914760
Molecular Weight369.48
Molecular FormulaC20H23N3O2S
SMILESO=C(NC(NC1=CC=C(NC(C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.7065 mL13.5325 mL27.0651 mL
5 mM0.5413 mL2.7065 mL5.4130 mL
10 mM0.2707 mL1.3533 mL2.7065 mL
50 mM0.0541 mL0.2707 mL0.5413 mL

Description

Tenovin-1 protects against MDM2-mediated degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of and . Tenovin-1 is also an inhibitor of .

Targets

p53 [1]Mdm2 [1]DHODH [2]

In vitro

Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.