Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.7065 mL
13.5325 mL
27.0651 mL
5 mM
0.5413 mL
2.7065 mL
5.4130 mL
10 mM
0.2707 mL
1.3533 mL
2.7065 mL
50 mM
0.0541 mL
0.2707 mL
0.5413 mL
Description
Tenovin-1 protects against MDM2-mediated degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of and . Tenovin-1 is also an inhibitor of .
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
