[CAS NO. 380315-80-0] Tenovin-1
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PRODUCTS SPECIFICATIONS [380315-80-0]
Catelog
SLK-S8000
Brand
Selleck
CAS
380315-80-0
DESCRIPTION [380315-80-0]
Overview
| MDL | MFCD02914760 |
|---|---|
| Molecular Weight | 369.48 |
| Molecular Formula | C20H23N3O2S |
| SMILES | O=C(NC(NC1=CC=C(NC(C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7065 mL | 13.5325 mL | 27.0651 mL |
| 5 mM | 0.5413 mL | 2.7065 mL | 5.4130 mL |
| 10 mM | 0.2707 mL | 1.3533 mL | 2.7065 mL |
| 50 mM | 0.0541 mL | 0.2707 mL | 0.5413 mL |
Description
Tenovin-1 protects against MDM2-mediated degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of and . Tenovin-1 is also an inhibitor of .
In vitro
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
References
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