[CAS NO. 28097-03-2] Chaetocin

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PRODUCTS SPECIFICATIONS [28097-03-2]

Catalog

SLK-S8068

Brand

Selleck

CAS

28097-03-2

DESCRIPTION [28097-03-2]

Overview

MDL	-
Molecular Weight	696.84
Molecular Formula	C30H28N6O6S4
SMILES	O=C1N2[C@@]3([C@@](C=4C(N3)=CC=CC4)(C[C@]25C(=O)N(C)[C@@]1(CO)SS5)[C@@]67[C@@](N8[C@]9(C6)C(=O)N(C)[C@](CO)(C8=O)SS9)(NC=%10C7=CC=CC%10)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.4350 mL	7.1752 mL	14.3505 mL
5 mM	0.2870 mL	1.4350 mL	2.8701 mL
10 mM	0.1435 mL	0.7175 mL	1.4350 mL
50 mM	0.0287 mL	0.1435 mL	0.2870 mL

Description

Chaetocin, a natural product from Chaetomium species, is a inhibitor with of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of .

Targets

dSU(VAR)3-9 ^[1]	mouse G9a ^[1]	Neurospora crassa DIM5 ^[1]
0.8 μM	2.5 μM	3 μM

In vitro

In SL-2 Drosophila tissue culture cells, Chaetocin causes the inhibition of SU(VAR)3-9 and the number of H3 molecules dimethylated at Lys9, and also inhibits cell growth. In HepG2, Hep3B, and Huh7 human hepatoma cells, Chaetocin inhibits HIF-1-Mediated hypoxic responses. Chaetocin also potently inhibits proliferation and colony formation in a broad range of cancer cell lines with IC50 of 2-10 nM.

References

[1] Greiner D, et al. Nat Chem Biol. 2005, 1(3), 143-145.
[2] Lee YM, et al. Hepatology. 2011, 53(1), 171-180.
[3] Isham CR, et al. Br J Cancer. 2012, 106(2), 314-323.
[4] Siddaway R, et al. Acta Neuropathol. 2022 Nov;144(5):1027-1048.

Synonyms

[10b,10′b(11H,11′H)-Bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone, 2,2′,3,3′,5a,5′a,6,6′-octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl-, (3S,3′S,5aR,5′aR,10bR,10′bR,11aS,11′aS)-

Chaetocin

Chetocin

3,11a-Epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole, bimol. deriv.

(3S,3′S,5aR,5′aR,10bR,10′bR,11aS,11′aS)-2,2′,3,3′,5a,5′a,6,6′-Octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl[10b,10′b(11H,11′H)-bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone

[10b,10′b(11H,11′H)-Bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone, 2,2′,3,3′,5a,5′a,6,6′-octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl-, [3S-[3α,5aβ,10bβ(3′R*,5′aS*,10′bS*,11′aR*),11aα]]-

(+)-Chaetocin A

(+)-Chaetocin

Chaetocin A