[CAS NO. 803647-40-7] NSC59984
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PRODUCTS SPECIFICATIONS [803647-40-7]
Catalog
SLK-S8106
Brand
Selleck
CAS
803647-40-7
DESCRIPTION [803647-40-7]
Overview
| MDL | MFCD29905462 |
|---|---|
| Molecular Weight | 265.27 |
| Molecular Formula | C12H15N3O4 |
| SMILES | O=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7697 mL | 18.8487 mL | 37.6974 mL |
| 5 mM | 0.7539 mL | 3.7697 mL | 7.5395 mL |
| 10 mM | 0.3770 mL | 1.8849 mL | 3.7697 mL |
| 50 mM | 0.0754 mL | 0.3770 mL | 0.7539 mL |
Description
NSC59984 is a pathway activator via induction of mutant p53 protein degradation and p73 activation.
Targets
| p53 [1] |
In vitro
NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells.
In vivo
In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner.
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