[CAS NO. 803647-40-7]  NSC59984

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PRODUCTS SPECIFICATIONS [803647-40-7]

Catelog
SLK-S8106
Brand
Selleck
CAS
803647-40-7

DESCRIPTION [803647-40-7]

Overview

MDLMFCD29905462
Molecular Weight265.27
Molecular FormulaC12H15N3O4
SMILESO=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM3.7697 mL18.8487 mL37.6974 mL
5 mM0.7539 mL3.7697 mL7.5395 mL
10 mM0.3770 mL1.8849 mL3.7697 mL
50 mM0.0754 mL0.3770 mL0.7539 mL

Description

NSC59984 is a pathway activator via induction of mutant p53 protein degradation and p73 activation.

Targets

p53 [1]

In vitro

NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells.

In vivo

In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner.