[CAS NO. 81624-55-7] NSC348884
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PRODUCTS SPECIFICATIONS [81624-55-7]
Catelog
SLK-S8149
Brand
Selleck
CAS
81624-55-7
DESCRIPTION [81624-55-7]
Overview
| MDL | MFCD12546137 |
|---|---|
| Molecular Weight | 636.79 |
| Molecular Formula | C38H40N10 |
| SMILES | CC1=CC=C2C(NC(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)=N2)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5704 mL | 7.8519 mL | 15.7038 mL |
| 5 mM | 0.3141 mL | 1.5704 mL | 3.1408 mL |
| 10 mM | 0.1570 mL | 0.7852 mL | 1.5704 mL |
| 50 mM | 0.0314 mL | 0.1570 mL | 0.3141 mL |
Description
NSC348884, as a inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with values ranging from 1.4-4 µM.
In vitro
NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53 and induces apoptosis.
In vivo
In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration..
References
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