[CAS NO. 81624-55-7]  NSC348884

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [81624-55-7]

Catelog
SLK-S8149
Brand
Selleck
CAS
81624-55-7

DESCRIPTION [81624-55-7]

Overview

MDLMFCD12546137
Molecular Weight636.79
Molecular FormulaC38H40N10
SMILESCC1=CC=C2C(NC(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)=N2)=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.5704 mL7.8519 mL15.7038 mL
5 mM0.3141 mL1.5704 mL3.1408 mL
10 mM0.1570 mL0.7852 mL1.5704 mL
50 mM0.0314 mL0.1570 mL0.3141 mL

Description

NSC348884, as a inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with values ranging from 1.4-4 µM.

Targets

nucleophosmin [1]
(In Granta cells)
nucleophosmin [1]
(In LNCaP cells)
1.7 μM4 μM

In vitro

NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53 and induces apoptosis.

In vivo

In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration..