[CAS NO. 1219810-16-8] RSL3
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PRODUCTS SPECIFICATIONS [1219810-16-8]
Catalog
SLK-S8155
Brand
Selleck
CAS
1219810-16-8
DESCRIPTION [1219810-16-8]
Overview
| MDL | MFCD30187526 |
|---|---|
| Molecular Weight | 440.88 |
| Molecular Formula | C23H21ClN2O5 |
| SMILES | O=C([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2682 mL | 11.3410 mL | 22.6819 mL |
| 5 mM | 0.4536 mL | 2.2682 mL | 4.5364 mL |
| 10 mM | 0.2268 mL | 1.1341 mL | 2.2682 mL |
| 50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL |
Description
RSL3 ((1S,3R)-RSL3) is a activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates and thus mediates GPX4-regulated ferroptosis.
Targets
| Gpx4 [1] (In Calu-1 cells) |
In vitro
Ferroptosis-inducing compounds inactivate GPX4 by direct binding or by depleting glutathione.After binding to GPX4, RSL3 inactivates GPX4 to induce ROS production from lipid peroxidation. RSL3's ability to induce synthetic lethality with oncogenic RAS is rapid and quite potent. This compound inhibits the growth of BJ-TERT/LT/ST/RASV12 and DRD cells as low as 10 ng/mland started to kill sensitive cells as early as 8 hr after treatment.
In vivo
Prostaglandin-endoperoxide synthase (PTGS) is the key enzyme in prostaglandin biosynthesis. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2. PTGS2 encoding cyclooxygenase-2 (COX-2) is significantly upregulated after treatment with RSL3 and erastin in mice.
References
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