[CAS NO. 1219810-16-8]  RSL3

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PRODUCTS SPECIFICATIONS [1219810-16-8]

Catelog
SLK-S8155
Brand
Selleck
CAS
1219810-16-8

DESCRIPTION [1219810-16-8]

Overview

MDLMFCD30187526
Molecular Weight440.88
Molecular FormulaC23H21ClN2O5
SMILESO=C([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.2682 mL11.3410 mL22.6819 mL
5 mM0.4536 mL2.2682 mL4.5364 mL
10 mM0.2268 mL1.1341 mL2.2682 mL
50 mM0.0454 mL0.2268 mL0.4536 mL

Description

RSL3 ((1S,3R)-RSL3) is a activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates and thus mediates GPX4-regulated ferroptosis.

Targets

Gpx4 [1]
(In Calu-1 cells)

In vitro

Ferroptosis-inducing compounds inactivate GPX4 by direct binding or by depleting glutathione.After binding to GPX4, RSL3 inactivates GPX4 to induce ROS production from lipid peroxidation. RSL3's ability to induce synthetic lethality with oncogenic RAS is rapid and quite potent. This compound inhibits the growth of BJ-TERT/LT/ST/RASV12 and DRD cells as low as 10 ng/mland started to kill sensitive cells as early as 8 hr after treatment.

In vivo

Prostaglandin-endoperoxide synthase (PTGS) is the key enzyme in prostaglandin biosynthesis. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2. PTGS2 encoding cyclooxygenase-2 (COX-2) is significantly upregulated after treatment with RSL3 and erastin in mice.