[CAS NO. 175026-96-7] NQDI-1

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PRODUCTS SPECIFICATIONS [175026-96-7]

Catelog

SLK-S8289

Brand

Selleck

CAS

175026-96-7

DESCRIPTION [175026-96-7]

Overview

MDL	MFCD03265970
Molecular Weight	319.31
Molecular Formula	C19H13NO4
SMILES	O=C(C1=C2C3=C(NC1=O)C=CC=C3C(C4=C2C=CC=C4)=O)OCC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1318 mL	15.6588 mL	31.3175 mL
5 mM	0.6264 mL	3.1318 mL	6.2635 mL
10 mM	0.3132 mL	1.5659 mL	3.1318 mL
50 mM	0.0626 mL	0.3132 mL	0.6264 mL

Description

NQDI 1, an inhibitor of , attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

Targets

ASK1 ^[3]
(Cell-free assay)

3 μM

In vivo

NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1.

References

[1] Hao H, et al. Mol Med Rep. 2016, 13(6):4585-4592.
[2] Eaton GJ, et al. Cell Death Dis. 2014, 5:e1522.
[3] Volynets GP, et al. J Med Chem. 2011, 54(8):2680-6.