[CAS NO. 1622848-92-3] GSK2982772
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PRODUCTS SPECIFICATIONS [1622848-92-3]
Catelog
SLK-S8484
Brand
Selleck
CAS
1622848-92-3
DESCRIPTION [1622848-92-3]
Overview
| MDL | MFCD30828708 |
|---|---|
| Molecular Weight | 377.40 |
| Molecular Formula | C20H19N5O3 |
| SMILES | O=C(C1=NC(CC2=CC=CC=C2)=NN1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6497 mL | 13.2485 mL | 26.4971 mL |
| 5 mM | 0.5299 mL | 2.6497 mL | 5.2994 mL |
| 10 mM | 0.2650 mL | 1.3249 mL | 2.6497 mL |
| 50 mM | 0.0530 mL | 0.2650 mL | 0.5299 mL |
Description
GSK2982772 is an ATP competitive inhibitor with the IC50 value of 16 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.
Targets
| human RIP1 [1] (Cell-free assay) |
| 16 nM |
In vitro
GSK2982772 has excellent activity in both RIP1 cellular systems, preventing TNF induced necrotic cell death, and an ulcerative colitis explant assay blocking spontaneous cytokine release.
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