Please click "REQUEST A QUOTE" button if there is no stock, or
you need other sizes or custom synthesis.
Catalog:
SLK-S8651
Brand:
Selleck
CAS:
722494-26-0
Overview
MDL
MFCD01862576
Molecular Weight
347.24
Molecular Formula
C6H4NO8V.2K
SMILES
OC1=CC=C(C(O[V](O[O-])(O[O])=O)=O)N=C1.[K+].[K+]
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.8799 mL
14.3993 mL
28.7985 mL
5 mM
0.5760 mL
2.8799 mL
5.7597 mL
10 mM
0.2880 mL
1.4399 mL
2.8799 mL
50 mM
0.0576 mL
0.2880 mL
0.5760 mL
Description
bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of with an of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
1 μM BpV(Hopic) treatment is capable of increasing the in vitro migration of C2C12 myoblasts, without significantly reducing their ability to differentiate and fuse into multinucleated myotubes. The effects on myoblast migration is in conjuction with enhanced AKT and ERK1/2 signaling.
In vivo
Pharmacological inhibition of PTEN with bpV(HOpic) exacerbates renal dysfunction and promotes tubular damage in mice with IRI(renal ischemia/reperfusion injury) compared with vehicle-treated mice with IRI. PTEN inhibition enhances tubular cell apoptosis in kidneys with IRI, which is associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expands the infiltration of neutrophils and macrophages into kidneys with IRI, which is accompanied by increased expression of the proinflammatory molecules.
