[CAS NO. 722494-26-0] bpV (HOpic)
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PRODUCTS SPECIFICATIONS [722494-26-0]
Catalog
SLK-S8651
Brand
Selleck
CAS
722494-26-0
DESCRIPTION [722494-26-0]
Overview
| MDL | MFCD01862576 |
|---|---|
| Molecular Weight | 347.24 |
| Molecular Formula | C6H4NO8V.2K |
| SMILES | OC1=CC=C(C(O[V](O[O-])(O[O])=O)=O)N=C1.[K+].[K+] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8799 mL | 14.3993 mL | 28.7985 mL |
| 5 mM | 0.5760 mL | 2.8799 mL | 5.7597 mL |
| 10 mM | 0.2880 mL | 1.4399 mL | 2.8799 mL |
| 50 mM | 0.0576 mL | 0.2880 mL | 0.5760 mL |
Description
bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of with an of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
Targets
| PTEN [1] (Cell-free assay) |
| 14 nM |
In vitro
1 μM BpV(Hopic) treatment is capable of increasing the in vitro migration of C2C12 myoblasts, without significantly reducing their ability to differentiate and fuse into multinucleated myotubes. The effects on myoblast migration is in conjuction with enhanced AKT and ERK1/2 signaling.
In vivo
Pharmacological inhibition of PTEN with bpV(HOpic) exacerbates renal dysfunction and promotes tubular damage in mice with IRI(renal ischemia/reperfusion injury) compared with vehicle-treated mice with IRI. PTEN inhibition enhances tubular cell apoptosis in kidneys with IRI, which is associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expands the infiltration of neutrophils and macrophages into kidneys with IRI, which is accompanied by increased expression of the proinflammatory molecules.
References
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