[CAS NO. 300802-28-2] CA3 (CIL56)
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PRODUCTS SPECIFICATIONS [300802-28-2]
Catelog
SLK-S8661
Brand
Selleck
CAS
300802-28-2
DESCRIPTION [300802-28-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 489.61 |
| Molecular Formula | C23H27N3O5S2 |
| SMILES | O=S(C1=CC2=C(C=C1)C3=C(C=C(S(=O)(N4CCCCC4)=O)C=C3)/C2=N\O)(N5CCCCC5)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
CA3 (CIL56) has potent inhibitory effects on transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces and iron-dependent .
Targets
| YAP/TEAD interaction [1] |
In vitro
CA3 strongly inhibits esophageal adenocarcinoma cell growth in vitro. CA3 can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells. CA3 specially inhibits Tead/YAP1 transcriptional activity but shows no inhibitory activity on other transcriptional factors-Super-TOP/Wnt, CBF1/Notch, and AP-1 after cotransfection of their respective individual promoter luciferases in 293T cells. CA3 preferentially inhibits CSC properties enriched in radiation-resistant esophageal adenocarcinoma cells.
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