[CAS NO. ] Elimusertib (BAY-1895344) hydrochloride

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PRODUCTS SPECIFICATIONS

Catalog

SLK-S8666

Brand

Selleck

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	411.89
Molecular Formula	C20H22ClN7O
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4278 mL	12.1392 mL	24.2783 mL
5 mM	0.4856 mL	2.4278 mL	4.8557 mL
10 mM	0.2428 mL	1.2139 mL	2.4278 mL
50 mM	0.0486 mL	0.2428 mL	0.4856 mL

Description

Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available inhibitor with an IC50 of 7 nM.

Targets

ATR ^[1]
(Cell-free assay)

7 nM

In vitro

In vitro, BAY 1895344 is shown to be a very potent and highly selective ATR inhibitor (IC50 = 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibits hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM).

References

[1] Ulrich T. Luecking, et al. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 983.
[2] Antje Margret Wengner, et al. AACR; Cancer Res 2017. 77(13 Suppl):Abstract nr 836.
[3] Tang Z, et al. Clin Cancer Res. 2021 Sep 1;27(17):4898-4909.