[CAS NO. 790702-57-7]  NGI-1 (ML414)

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PRODUCTS SPECIFICATIONS [790702-57-7]

Catelog
SLK-S8750
Brand
Selleck
CAS
790702-57-7

DESCRIPTION [790702-57-7]

Overview

MDLMFCD06358908
Molecular Weight394.51
Molecular FormulaC17H22N4O3S2
SMILESO=C(NC1=NC=C(C)S1)C2=CC(S(=O)(N(C)C)=O)=CC=C2N3CCCC3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.5348 mL12.6739 mL25.3479 mL
5 mM0.5070 mL2.5348 mL5.0696 mL
10 mM0.2535 mL1.2674 mL2.5348 mL
50 mM0.0507 mL0.2535 mL0.5070 mL

Description

NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both isoforms and therefore may exhibit antiviral activity against flaviviruses.

Targets

oligosaccharyltransferase (OST) [1]

In vitro

NGI-1 is a reversible catalytic subunit inhibitor of the oligosaccharyltransferase (OST) that has higher specificity for STT3B compared to STT3A (STT: OST catalytic subunit). In non-small cell lung cancer cells NGI-1 blocks cell surface localization and signaling of the EGFR glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or FGFR) for survival. In these cell lines OST inhibition causes cell cycle arrest accompanied by induction of p21, autofluorescence, and changes in cell morphology; all hallmarks of senescence. NGI-1 exhibits broad antiviral activity against multiple flaviviruses. It blocks viral RNA replication independent of inhibition of the catalytic activity of the OST complex.