Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.4032 mL
7.0160 mL
14.0319 mL
5 mM
0.2806 mL
1.4032 mL
2.8064 mL
10 mM
0.1403 mL
0.7016 mL
1.4032 mL
50 mM
0.0281 mL
0.1403 mL
0.2806 mL
Description
VU661013 is a novel, potent, selective inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to in AML.
VU661013 is a novel, potent, selective MCL-1 inhibitor that de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells.
