Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
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1 mg
5 mg
10 mg
1 mM
1.4068 mL
7.0341 mL
14.0683 mL
5 mM
0.2814 mL
1.4068 mL
2.8137 mL
10 mM
0.1407 mL
0.7034 mL
1.4068 mL
50 mM
0.0281 mL
0.1407 mL
0.2814 mL
Description
S55746 (S 055746,BCL201) is a novel, orally active specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
S55746 occupies the hydrophobic groove of BCL-2. In a panel of hematological cell lines, S55746 induces hallmarks of apoptosis including externalization of phosphatidylserine, caspase-3 activation and PARP cleavage. S55746 potently induces RS4;11 cell killing after 72 h of treatment with an IC50 of 71.6 nM and exhibits a much weaker activity in H146 (IC50 = 1.7 μM), a BCL-XL-dependent cell line, which expresses a low level of BCL-2 and high level of BCL-XL. It has no cytotoxic activity on BCL-XL-dependent cells, such as platelets.
