[CAS NO. 2158197-70-5] HS-1371
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PRODUCTS SPECIFICATIONS [2158197-70-5]
Catelog
SLK-S8775
Brand
Selleck
CAS
2158197-70-5
DESCRIPTION [2158197-70-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 384.47 |
| Molecular Formula | C24H24N4O |
| SMILES | CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6010 mL | 13.0049 mL | 26.0098 mL |
| 5 mM | 0.5202 mL | 2.6010 mL | 5.2020 mL |
| 10 mM | 0.2601 mL | 1.3005 mL | 2.6010 mL |
| 50 mM | - | - | - |
Description
HS-1371 is a potent inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.
Targets
| RIP3 kinase [1] |
| 20.8 nM |
In vitro
HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3 at the basal level. It displays a complete inhibitory effect on TNF-induced necroptosis signaling, showing no phosphorylation of RIP3 and MLKL in HT-29 cells. Inhibition of RIP3 kinase activity by HS-1371 blocks necrosome complex formation, showing disruption of MLKL recruitment. HS-1371 rescues cells from TNF-induced necroptosis. It rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.
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