Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.9547 mL
9.7735 mL
19.5469 mL
5 mM
0.3909 mL
1.9547 mL
3.9094 mL
10 mM
0.1955 mL
0.9773 mL
1.9547 mL
50 mM
-
-
-
Description
ML385 is a novel and specific inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several and lipid peroxidation-related proteins.
ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination with carboplatin. The PK profile tested in CD-1 mice shows that ML385 has a half-life (t = 2.82 h) after IP injection (30 mg/kg). ML385 could alleviate the pancreatic injury.
