Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.8564 mL
9.2819 mL
18.5639 mL
5 mM
0.3713 mL
1.8564 mL
3.7128 mL
10 mM
0.1856 mL
0.9282 mL
1.8564 mL
50 mM
0.0371 mL
0.1856 mL
0.3713 mL
Description
V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks and the as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.
V-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency (IC50 V-9302 = 9.6 µM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 µM).
