Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.3790 mL
11.8951 mL
23.7903 mL
5 mM
0.4758 mL
2.3790 mL
4.7581 mL
10 mM
0.2379 mL
1.1895 mL
2.3790 mL
50 mM
0.0476 mL
0.2379 mL
0.4758 mL
Description
Unesbulin (PTC596) is a second-generation inhibitor that accelerates BMI-1 degradation. PTC596 downregulates and induces p53-independent mitochondrial . IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.
PTC596 induces mitochondrial apoptosis in BMI-1-expressing MCL cells in a p53-independent manner. MCL SP cells were susceptible to PTC596-induced apoptosis.
