[CAS NO. 1610964-64-1] Unesbulin (PTC596)
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PRODUCTS SPECIFICATIONS [1610964-64-1]
Catalog
SLK-S8820
Brand
Selleck
CAS
1610964-64-1
DESCRIPTION [1610964-64-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 420.34 |
| Molecular Formula | C19H13F5N6 |
| SMILES | NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C(C)=NC4=CC=C(F)C=C34)=N1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3790 mL | 11.8951 mL | 23.7903 mL |
| 5 mM | 0.4758 mL | 2.3790 mL | 4.7581 mL |
| 10 mM | 0.2379 mL | 1.1895 mL | 2.3790 mL |
| 50 mM | 0.0476 mL | 0.2379 mL | 0.4758 mL |
Description
Unesbulin (PTC596) is a second-generation inhibitor that accelerates BMI-1 degradation. PTC596 downregulates and induces p53-independent mitochondrial . IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.
Targets
| BMI-1 [1] |
In vitro
PTC596 induces mitochondrial apoptosis in BMI-1-expressing MCL cells in a p53-independent manner. MCL SP cells were susceptible to PTC596-induced apoptosis.
References
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