[CAS NO. 1610964-64-1]  Unesbulin (PTC596)

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PRODUCTS SPECIFICATIONS [1610964-64-1]

Catelog
SLK-S8820
Brand
Selleck
CAS
1610964-64-1

DESCRIPTION [1610964-64-1]

Overview

MDL-
Molecular Weight420.34
Molecular FormulaC19H13F5N6
SMILESNC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C(C)=NC4=CC=C(F)C=C34)=N1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.3790 mL11.8951 mL23.7903 mL
5 mM0.4758 mL2.3790 mL4.7581 mL
10 mM0.2379 mL1.1895 mL2.3790 mL
50 mM0.0476 mL0.2379 mL0.4758 mL

Description

Unesbulin (PTC596) is a second-generation inhibitor that accelerates BMI-1 degradation. PTC596 downregulates and induces p53-independent mitochondrial . IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.

Targets

BMI-1 [1]

In vitro

PTC596 induces mitochondrial apoptosis in BMI-1-expressing MCL cells in a p53-independent manner. MCL SP cells were susceptible to PTC596-induced apoptosis.