Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.5448 mL
12.7239 mL
25.4479 mL
5 mM
0.5090 mL
2.5448 mL
5.0896 mL
10 mM
0.2545 mL
1.2724 mL
2.5448 mL
50 mM
0.0509 mL
0.2545 mL
0.5090 mL
Description
Gboxin is an inhibitor of in cancer cells. Gboxin inhibits the activity of . It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.
Gboxin rapidly and irreversibly compromises GBM oxygen consumption. Reliant on its positive charge, Gboxin associates with mitochondrial oxidative phosphorylation complexes in a proton gradient dependent manner and inhibits F0F1 ATP synthase activity. Gboxin targets unique features of mitochondrial pH in GBM and other cancer cells, independent of their genetic composition, and exerts its tumor cell specific toxicity in primary culture and in vivo.
